Gene Transfer and Somatic Cell Engineering Facility
directed by Isabelle Rivière
212-639-7600 ext. 7600
a member since 4/8/2008

Contact Info

For information contact
Isabelle Rivière.

(212) 639-7600 ext. 7600
Memorial Sloan Kettering Cancer Center
1275, York Avenue
S-1014, Box 182
New York, NY 10021


Services Provided

This facility provides research grade material and offers production support to Academics.

Biologics Produced

  • Vaccines
  • Hematopoietic Progenitor Cells
  • Bacteria
  • Antigen Specific T-cells

Vector Support

  • Retrovirus
  • Plasmid DNA

Notable Affiliations


About this facility

The role of the Gene Transfer and Somatic Cell Engineering Facility is to support preclinical and clinical research in the following functions: 1) Genetic engineering and ex vivo transduction of patient cells (hematopoietic stem cells, dendritic cells, and lymphocytes). 2) Vector production (clinical-grade plasmid DNA and retroviral vectors). 3) Research and development work relating to vector production and transduction of patient cells. 4) Molecular analysis of gene transfer efficiency and transgene expression in patient cells and tissues (FACS analysis, real-time PCR, immunostaining, etc.). 5) Quality control and biosafety testing of clinical reagents and patient cells. Currently, the projects revolve around the development of gene transfer approaches for the treatment of melanoma and various types of lymphoma. These projects involve the production of plasmid DNA vaccines; the generation of genetically modified CD34+ cells, dendritic cells and genetically targeted T lymphocytes; as well as the engineering of artificial antigen presenting cells.