Clinical Vector Core, Center for Cellular and Molecular Therapeutics, The Childrens Hospital of Philadelphia
directed by Johannes van der Loo
(267) 425-2011
a member since 6/13/2008

Contact Info

For information contact
Johannes van der Loo.

(267) 425-2011
The Childrens Hospital of Philadelphia,Colket Translational Res Bldg
3501 Civic Center Blvd, CTRB-5054
Philadelphia, PA 19104

USA
(267) 425-2011
(267) 425-2011

Services Provided

offers production support to Academics.

Misc Services

  • Regulatory support (US compliant) for Investigational New Drug (IND) applications
  • Letter of cross reference to our Drug Master File (DMF)

Vector Support

  • Long-term stability (3 4 5 years) consistent with the duration of the Phase 1/2 study
  • Manufaturing of clinical or non-clinical excipient.
  • Manufacturing of clinical and non clinical AAV and LV vectors per client potency specifications and industry standards for safety identity purity and potency
  • Lentivirus
  • Devise compatibility and short-term stability studies (as required)
  • AAV

Notable Affiliations

NHLBI Gene Therapy Resource Program

About this facility

The Clinical Vector Core at the Children’s Hospital of Philadelphia is a nonprofit facility that provides high quality gene therapy vectors to investigators nationally and internationally in support of early phase clinical trials.

 The core provides manufacturing of clinical and pre-clinical Adeno-Associated Virus (AAV) vectors of serotypes 1, 2, 5, 6, 8, 9, and Lentivirus (LV) vectors. Novel and modified serotypes will require development prior to scale up.

Products for clinical use are manufactured in compliance with Current Good Manufacturing Practices (cGMP) for Phase 1 and 2 clinical trials.

To support pre-clinical work, including pharmacology and toxicology studies, we offer products manufactured using a GMP-comparable process. Research grade products for proof-of- principle and bridging studies are also offered.