Indiana University Vector Production Facility
directed by Kenneth Cornetta, MD
(317) 278-1328
a member since 1/24/2008

Contact Info

For information contact
Kenneth Cornetta, MD.

(317) 278-1328
Indiana University School of Medicine
980 W. Walnut St.
Indianapolis, IN 46202

USA

Services Provided

offers production support to both Academics and Companies.

Misc Services

  • Repository for clinical trial samples and preclinical toxicology sample archive
  • SeqMap Bioinformatics tool for insertional site mapping
  • cGMP Safety Testing Services
  • Vector titering
  • FACS
  • PCR and qPCR assays

Vector Support

  • Retrovirus
  • Lentivirus

Notable Affiliations

GTRP,NHLBI,NCRR,NGVB

About this facility

The IU VPF is a core laboratory within the Indiana University School of Medicine and the Department of Medical and Molecular Genetics and is dedicated to the development, production and testing of gene therapy technology. The IU VPF is directed by Dr. Kenneth Cornetta, Chairman of Medical and Molecular Genetics, and the Vice President of the American Society for Gene Therapy. Indiana University is also the Core Laboratory for the National Heart, Lung and Blood Institute (NHLBI) funded Gene Therapy Research Program for production of lentiviral vectors, https://www.qa.gtrp.org/lab_ind.aspx

The production facility contains two production suites that are dedicated to specific vector systems. One suite is used to produce retroviral vectors and the other is used to produce lentiviral vectors.

In addition to the production services, the IU VPF offers a wide variety of routine and specialized assays important in safety testing and certifying both clinical and non-clinical grade vectors. Vector titering is available using cell culture, while FACS, PCR and quantitative PCR assays are available to accommodate a wide variety of vector constructs. Quantitative PCR is also available to measure transduction efficiency in-vitro and in-vivo.

To date, the IU VPF has certified over 30 vectors for clinical trials throughout the United States and abroad.